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Iron overload disorder : ウィキペディア英語版
Iron overload

Iron overload, also known as hemochromatosis or haemochromatosis, indicates accumulation of iron in the body from any cause. The most important causes are hereditary haemochromatosis (HHC), a genetic disorder, and transfusional iron overload, which can result from repeated blood transfusions.〔
==Signs and symptoms==
Organs commonly affected by haemochromatosis are the liver, heart, and endocrine glands.
Haemochromatosis may present with the following clinical syndromes:
* Cirrhosis of the liver: Varies from zonal iron deposition〔Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol Int. 1995 Mar;45(3):202-6. PubMed
PMID 7787990.〕 to fibrosis (cirrhosis).
* Diabetes due to selective iron deposition in pancreatic islet beta cells leading to functional failure and cell death.〔Lu JP, Hayashi K. Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases. Pathol Int. 1994 Mar;44(3):194-9. PubMed PMID 8025661.〕〔Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol Int. 1995 Mar;45(3):202-6. PubMed PMID 7787990.〕
* Cardiomyopathy
* Arthritis (calcium pyrophosphate deposition in joints)
* Testicular failure
* Slate grey discoloration of the skin
* Joint pain and bone pain〔http://www.mayoclinic.com/health/hemochromatosis/DS00455/DSECTION=symptoms〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Iron overload」の詳細全文を読む



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